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The autophagy regulator Atg 5 induces caspase activation by interacting with the adaptor protein FADD, a component of the extrinsic apoptosis pathway. Alternatively, cleavage of Atg 5 by calpain causes the truncated Atg 5 protein to translocate to the mitochondria to induce MOMP resulting in cytochrome c release and caspase activation.
