Figure 1.

sTAB induces clinical heart failure. A, Representative 4-chamber sections of mouse hearts 7 days after sham or sTAB surgery. Scale bar=1 mm. B, Seven days after sTAB, animals demonstrated signs of heart failure with significant increases in heart mass, lung mass (indicative of pulmonary edema), and impairment in systolic performance. Mean data from sham (n=5) and sTAB (n=5) mice subjected to surgery as listed. HW/BW indicates heart weight/body weight; LWeight, lung weight. *P<0.05.