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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Neuropharmacology. 2008 May 9;55(2):148–153. doi: 10.1016/j.neuropharm.2008.05.002

Fig. 2.

Fig. 2

Long-term (14 days) treatment with zolpidem or diazepam but not imidazenil results in anticonvulsant tolerance action. Rats treated for 14 days with vehicle or with increasing doses of zolpidem, diazepam, or imidazenil (see method for dosing schedule) were left drug free for 18 h and then received acute oral pretreatment with zolpidem (48.8 µmol/kg), diazepam(17.6µmol/kg) or imidazenil(2.5µmol/kg) 30 min before prior to receiving bicuculline infusion. Each bar is the mean ± SEM for 6 rats. Data were subjected to ANOVA followed by Dunnet’s multiple range test.*p<0.05 versus rats that received 14 days of vehicle treatment.