Table 2.

Studies evaluating total fat intake and endometrial cancer risk

Reference	Country	Age	Cases/ Controls or total cohort	Exposure evaluated	Contrast	RR/O R	95% confidence interval	P for trend	Covariates Considered*
									A	B	E	S	H	R
Cohort studies
Jain et al., 2000 [26]†	Canada	40-59	221/3,697	Total fat, g/day	>102.8 vs. <85.9 g	0.84	0.58, 1.23		1	1	1	1	1	2
Furberg et al., 2003 [27]	Norway		130/24,460	Total fat, g/day	Per 19.4 g	0.99	0.82, 1.2		1
Population-based case-control studies
Potischman et al., 1993 [23]	United States	20-74	399/296	Fat calories, kcal/day	>634 vs. <344 kcal	1.5	0.8, 2.7		1	1	‡	1	1	1
				% Calories from fat	>43.4% vs. <32.2%	1.5	0.9, 2.4		1	1	1	1	1	1
Shu et al., 1993 [28]	China	18-74	268/268	Calories from fat	≥659.32 vs. ≤475.20 kcal	3.9	2.2, 6.8	<0.01	1	1				1
Goodman et al., 1997 [30]§	United States	18-84	332/511	Fat calories	≥847 vs. <420 kcal	1.60	0.97, 2.61	0.04	(1)	1			1	1
				Fat, g/day	>94.1 vs. <46.7 g	1.68	0.77, 3.69	0.17	(1)	1	1		1	1
Goodman et al., 1997 [29]§	United States	18-84	332/511	% Calories from fat	>38.1 vs. <27.9%	1.6		0.11	(1)	1	1		1	1
Jain et al., 2000 [31]	Canada	30-79	552/562	Total fat, g/day	>66.3 vs. <46 g	1.21	0.84, 1.83	0.65	1	1	1	1	1	2
					Per 20 g	1.12	0.95, 1.33		1	1	1	1	1	2
McCann et al., 2000 [32]	United States	40-85	232/639	Total fat, g/day	>102 vs. ≤60 g	1.6	0.7, 3.4	0.75	1	1	1	1	1	3
Littman et al., 2001 [25]	United States	45-74	679/944	% Calories from fat	>45.1% vs. <30.8%	1.7	1.2, 2.4	0.006	1	1	1	1	1
Hospital-based case-control studies
Salazar-Martinez et al., 2005 [33]	Mexico	18-81	85/629	Total fat, g/day	>59 vs. <37 g	1.45	0.61, 3.44	0.54	1	1	1			1

^*Adjustment columns: A = Age; B = BMI/weight; E = Total Energy; S = Smoking; H = HRT/ERT use; R = Reproductive factors; (1): matched on age. Numbers in columns refer to the number of covariates adjusted for under that grouping.

^†Case-cohort design.

^‡Adjusted for carbohydrate calories.

^§Same case-control study.

Abbreviations: OR: odds ratio, RR: relative risk.