Table 3.

Studies evaluating saturated fat intake and endometrial cancer risk

Reference	Country	Age	Cases/ Controls or total cohort	Exposure evaluated	Contrast	RR/OR	95% confidence interval	P for trend	Covariates Considered*
									A	B	E	S	H	R
Cohort studies
Jain et al., 2000 [26]†	Canada	40-59	221/3,697	Saturated fat, g/day	Q4 vs. Q1	0.7	0.47, 1.04		1	1	1	1	1	2
Population-based case-control studies
Potischman et al., 1993 [23]	United States	20-74	399/296	Saturated fat, g/day	>25 vs. <12 g	2.1	1.2, 3.7		1	1	‡	1	1	1
Goodman et al., 1997 [29]	United States	18-84	332/511	Saturated fat, g/day	>27.2 vs. <12.5 g	2.2		0.13	(1)	1	1		1	1
Jain et al., 2000 [31]	Canada	30-79	552/562	Saturated fat, g/day	Q4 vs. Q1	1.22	0.85, 1.75	0.57	1	1	1	1	1	2
					Per 12 g.	1.19	0.96, 1.46		1	1	1	1	1	2
McCann et al., 2000 [32]	United States	40-85	232/639	Saturated fat, g/day	>37 vs. ≤21 g	1.1	0.5, 2.4	0.75	1	1	1	1	1	3
Littman et al., 2001 [25]	United States	45-74	679/944	Saturated fat, g/day	>33.4 vs. <13.3 g	1.6	1.1, 2.3	0.001	1	1	1	1	1
Hospital-based case-control studies
Tzonou et al., 1996 [34]	Greece		145/298	Saturated fat, g/day	Per 8 g	0.94	0.64, 1.38		1	1	1	1	1	5
Salazar-Martinez et al., 2005 [33]	Mexico	18-81	85/629	Saturated fat, g/day	>25 vs. <17 g	0.67	0.29, 1.53	0.08	1	1	1			1

^*Adjustment columns: A = Age; B = BMI/weight; E = Total Energy; S = Smoking; H = HRT/ERT use; R = Reproductive factors; (1): matched on age. Numbers in columns refer to the number of covariates adjusted for under that grouping.

^†Case-cohort design.

^‡Adjusted for carbohydrate calories.

Abbreviations: OR: odds ratio, RR: relative risk; Q: quantile.