Table 5.

Studies evaluating polyunsaturated fatty acids intake and endometrial cancer risk

Reference	Country	Age	Cases/ Controls or total cohort	Exposure evaluated	Contrast	RR/OR	95% confidence interval	P for trend	Covariates Considered*
									A	B	E	S	H	R
Cohort studies
Jain et al., 2000 [26]†	Canada	40-59	221/3,697	Linoleic acid, g/day	>14 vs. <9.2 g	1.11	0.77, 1.61		1	1	1	1	1	2
Population-based case-control studies
Goodman et al., 1997 [29]	United States	18-84	332/511	Polyunsaturated fat, g/day	>27 vs. <13.3 g	1.5		0.17	(1)	1	1		1	1
McCann et al., 2000 [32]	United States	40-85	232/639	Polyunsaturated fat, g/day	>15 vs. ≤8 g	1	0.5, 1.8	0.58	1	1	1	1	1	3
Jain et al., 2000 [31]	Canada	30-79	552/562	Linolenic acid, g/day	>1.6 vs. ≤0.8 g	1.02	0.72, 1.46	0.99	1	1	1	1	1	2
				Linoleic acid, g/day	>9 vs. <5.9 g	1.14	0.81, 1.61	0.48	1	1	1	1	1	2
Potischman et al., 1993 [23]	United States	20-74	399/296	Linoleic acid, g/day	>14 vs. <7 g	1.6	0.9, 2.8		1	1	‡	1	1	1
Littman et al., 2001 [25]	United States	45-74	679/944	Linoleic acid, g//1000 kcal/day	>18.9 vs. <6.9 g	1	0.74, 1.5	0.94	1	1	1	1	1
Hospital-based case-control studies
Tzonou et al., 1996 [34]	Greece		145/298	Polyunsaturated fat, g/day	Per 8 g	1.02	0.8, 1.3		1	1	1	1	1	5
Salazar-Martinez et al., 2005 [33]	Mexico	18-81	85/629	Polyunsaturated fat, g/day	>5.8 vs. <4.2 g	2.23	0.98, 5.05	0.34	1	1	1			1

^*Adjustment columns: A = Age; B = BMI/weight; E = Total Energy; S = Smoking; H = HRT/ERT use; R = Reproductive factors; (1): matched on age. Numbers in columns refer to the number of covariates adjusted for under that grouping.

^†Case-cohort design.

^‡Adjusted for carbohydrate calories.

Abbreviations: OR: odds ratio, RR: relative risk.