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. Author manuscript; available in PMC: 2008 Dec 12.
Published in final edited form as: J Cereb Blood Flow Metab. 2007 Jul 18;28(2):341–353. doi: 10.1038/sj.jcbfm.9600528

Figure 4.

Figure 4

Protective effect of mucosal tolerance to E-selectin against white matter damage. (A) Photomicrographs of luxol fast blue staining of the corpus callosum, caudoputamen, and optic nerve (scale bars=50 μm). (B) Photomicrographs of the immunohistochemical staining for the cocktail of monoclonal antibodies directed against nonphosphorylated neurofilaments (SMI 311) of the corpus callosum and caudoputamen (scale bars=50 μm). The extent of the white matter rarefaction was less severe in the E-selectin-treated and sham-operated rats, as compared with PBS group. (C) Histograms of the fiber densities of the corpus callosum, caudoputamen, and optic nerve in rats subjected to a sham operation or to bilateral ligation of the carotid arteries and intranasal administration of either PBS or E-selectin on a booster tolerization schedule. The fiber densities in E-selectin-treated animals were significantly higher than those in PBS-treated animals.