Table 2.

VNS Peaks in Talairach (88) coordinates for contrast: Chronic 1 Year vs. Baseline

Location	X	Y	Z	Z-score	Cluster size (mm³)
Increase with VNS treatment
Left Lingual Gyrus, BA19	−26	−73	−4	5.3	4339
Left Lingual Gyrus, BA17	−19	−91	−4	4.0
Left Parietal, Sub-Gyral	−35	−40	34	5.1	5148
Left Parietal, Post-central gyrus, BA3	−21	−37	67	4.8	12723
Left Frontal Lobe, Paracentral Lobule, BA5	−12	−31	49	3.8
Left Precuneus, BA7	−12	−42	54	3.7
Right Post-central gyrus, BA2	21	−37	67	3.6
Left Superior Frontal Gyrus, BA6	−21	−4	67	3.5
Right Precuneus, BA7	19	−55	45	4.6	2437
Left Precuneus, BA7	−19	−64	34	4.0	467
Right Lingual Gyrus, BA19	28	−73	−4	3.9	1139
Right Middle Occipital Gyrus, BA18	19	−87	4	3.6
Left Cingulate Gyrus, BA24	−10	−10	34	3.6	159
Right Lingual Gyrus, BA17	3	−94	−2	3.4	45
Decrease with VNS treatment
Left Precentral Gyrus, BA6	−42	3	34	−5.3	112
Right Thalamus – Medial dorsal nucleus	10	−17	7	−5.0	445
Left Thalamus – Medial dorsal nucleus	−8	−19	7	−4.2
Right Medial Frontal Gyrus, BA25	6	26	−16	−4.8	612
Left Anterior Cingulate, BA32	−1	35	−7	−4.5
Right Middle Frontal Gyrus, BA10	35	46	16	−3.8	57
Right Middle Frontal Gyrus, BA9 / BA44	37	8	31	−3.7	18
Left Transverse Temporal Gyrus, BA41	−44	−28	11	−3.6	24
Left Fusiform Gyrus, BA20	−53	−31	−20	−3.6	9

Note: The name of regions that are shown indented without a corresponding cluster size localize to local maxima within a cluster whose global maximum is un-indented with a listed cluster size. Note that the order in the list is based upon Z-score.