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Stereoview of the lowest energy conformation of RSA504 (Tyr-D-Nle-Gly-Trp-Nle-Asp-Phe-NH2) based on a Monte Carlo conformational search. D-Nle and Nle are oriented on the same side and the terminal alkyl groups are in close proximity to each other. These sites were used for substituting residues appropriate for cyclization.
