Table 2.

Results from substitution tests in LSD-trained rats. All drugs were injected 30 min before tests. N = number of rats used for tests. % D = the percentage of rats with disrupted behavior. % SDL = the percentage of rats that selected the drug-appropriate lever. If the drug was one that completely substituted for the training drug, the method of Litchfield and Wilcoxon²⁰ was used to determine the ED50 and 95% confidence interval (95% CL).

Drug	Dose		N	% D	% SDL	ED50 (95% CL)
	mg/kg	μmole/kg				mg/kg	μmole/kg
1	0.25	0.80	13	46	29	0.35	1.06
	0.38	1.21	10	40	50	(0.27-0.46)	(0.82-1.36)
	0.50	1.61	14	36	89
4b	0.09	0.25	12	0	33	0.14	0.38
	0.17	0.50	11	0	54	(0.08-0.23)	(0.24-0.60)
	0.35	1.00	12	0	83
5b	0.17	0.50	12	17	10	0.40	1.16
	0.35	1.00	12	0	41	(0.26-0.61)	(0.77-1.75)
	0.69	2.00	10	0	80