Figure 2.

Hyperoxic reperfusion leads to increased unmetabolized glucose and increased [3-¹³C]lactate in the hippocampus and cortex. A, The amount of unmetabolized ¹³C-glucose was significantly higher in the hippocampus and cortex of animals resuscitated under hyperoxic conditions compared with nonischemic controls. The trend toward increased unmetabolized [1-¹³C]glucose in animals resuscitated under normoxic conditions was not significant (P=0.1). B, Although not significant (P=0.06), there was a trend toward elevated ¹³C labeling in the C3 position of lactate in the hippocampus of animals reperfused under hyperoxic, but not normoxic, conditions compared with nonischemic controls. There was no difference in ¹³C incorporation into lactate in the cortex. Values are mean±SE for n=7 nonischemic controls, 7 hyperoxic animals, and 6 normoxic animals. *Significantly different from nonischemic controls; 1-way ANOVA with Tukey post hoc analysis, P<0.05.