Table II.
Lymphoid DC subsets in the LRLN
| Treatmentb |
L-Selectinc |
P1d | P2e Naive vs Treatment
|
||||
|---|---|---|---|---|---|---|---|
| DC Subset a | Ad2/βGal-2 | LPS | −/− | +/+ | −/− vs. +/+ | −/− | +/ + |
| LRLN CD8+ | – | – | 14.4 ± 1.6 | 28.4 ± 3.6 | 0.004 | - | - |
| “ | + | – | 16.7 ± 2.9 | 29.4 ± 3.1 | 0.006 | NS | NS |
| “ | + | + | 31.7 ± 4.7 | 36.9 ± 4.3 | NS | 0.003 | NS |
| LRLN CD8− | – | – | 84.5 ± 1.6 | 71.0 ± 3.8 | 0.007 | - | - |
| “ | + | – | 81.6 ± 2.8 | 69.6 ± 3.1 | 0.009 | NS | NS |
| “ | + | + | 67.1 ± 5.0 | 61.8 ± 4.5 | NS | 0.004 | NS |
Pulmonary DCs were gated on lymphocytes that were CD11c low TCRαβ−.
DCs were derived from naive, Ad2/βGal-2-dosed, or Ad2/βGal-2 + LPS-dosed mice.
−/− = L-Selectin-deficient mice; +/+ = B6 mice. Data presented as mean ± SEM.
p-value between L-Sel−/− and L-Sel +/+ DC subsets (n = 10 mice/group); NS = not significant.
p-value between treatments within L-Sel−/− or L-Sel +/+ groups.