Figure 8.

Distribution of protein domains and families in computationally predicted and experimentally validated pADPr binding proteins. The graph shows the number of occurrences for the 12 most common Pfam domains in (A) putative pADPr binding proteins identified through a 90% similarity sequence search based on the original consensus pADPr binding motif (Supplementary Table S1), (B) a sub-dataset of putative pADPr binding proteins corresponding to the refined pADPr binding module derived from peptides polymer blot analysis (Supplementary Table S2) and (C) pADPr-associated proteins identified by MS in anti-pADPr immunoprecipitation assays in SK-N-SH cells following alkylation-induced DNA damage (Supplementary Table S3).