Figure 7.

Structural comparison of LldR and FadR–acyl–CoA complexes. (A) Comparison of the ligand-binding domains of LldR and FadR–acyl–Co complex. The structures of LldR and FadR–acyl–CoA complexes are shown as a Cα trace, coloured blue and red, respectively. The acyl–CoA is represented as a stick model. In LldR, the cavity is shown as a magenta chicken wire structure, and water molecules and the zinc ion occupying the cavity are shown as cyan and pink balls, respectively. (B) Putative switch region of LldR. The two monomers are coloured blue and cyan. The contacting residues between helix α4 and the boundary of the putative ligand-binding cavity, and between helix α4 and the DNA-binding domain (N′-domain), are shown as a stick model.