Figure 1.

Schematic representation of human SECISBP2 transcript variants. (A) Genomic organisation of SECISBP2 showing the 17 exons and their sizes in base pairs (bp). Locations of the functional domains are indicated. (B) Alternatively spliced SECISBP2 transcript variants generated through different exon combinations are shown schematically. Arrowheads indicate translation start sites. Designation for the encoded protein isoforms, the corresponding Met start codon number [based on numbering in the full-length human SBP2 sequence (NP_076982)] and predicted molecular weights (MW) of isoforms are indicated to the right of each transcript. (C) An alternative reading frame used for translation of the mitochondrial SBP2 isoform (mtSBP2) initiates in exon 2 (indicated by arrow). The encoded mitochondrial targeting sequence is underlined.