Figure 5. The activation HSP60-specific anti-ergotypic T cells requires co-stimulation.

Monoclonal antibodies to CD28, CD80 or CD86, or a control IgG (Control), were assayed for their ability to block the anti-ergotypic proliferative response of Anti-HSP60 T-cells (Line) or of LNC prepared from pHSP60-vaccinated rats (LNC). Results are presented as the percent of inhibition of proliferation±SEM of quadruplicate cultures. Three independent experiments produced similar results.