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Dilution experiment for determination of reversibility in vitro. A, the dilution protocol is described under “Experimental Procedures.” Upon 100-fold dilution, SAHA lost most of its activity against HDAC1. For inhibitor 106, the loss in inhibitory activity was significantly lower. B, upon 100-fold dilution, SAHA lost most of its activity against HDAC3. For inhibitor 106, essentially no loss in inhibitory activity was observed.
