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. Author manuscript; available in PMC: 2008 Dec 15.
Published in final edited form as: J Med Chem. 2006 Feb 23;49(4):1420–1432. doi: 10.1021/jm050797a

Scheme 1.

Scheme 1

General Heffe synthesis of 1-(4-substitutedphenyl)-2-pyrrolidin-1-yl-pentan-1-ones, 4ab

aReagents and conditions: i) n-BuMgCl; ii) H2SO4; iii) AlCl3, Br2; iv) pyrrolidine

bThe Heffe synthesis was not followed for certain compounds. Synthetic details for those compounds are presented in the Experimental Section and are discussed in the text.