General Heffe synthesis of 1-(4-substitutedphenyl)-2-pyrrolidin-1-yl-pentan-1-ones, 4ab
aReagents and conditions: i) n-BuMgCl; ii) H2SO4; iii) AlCl3, Br2; iv) pyrrolidine
bThe Heffe synthesis was not followed for certain compounds. Synthetic details for those compounds are presented in the Experimental Section and are discussed in the text.