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. Author manuscript; available in PMC: 2008 Dec 15.
Published in final edited form as: Protein Eng Des Sel. 2008 Jan 31;21(4):223–231. doi: 10.1093/protein/gzm093

Fig. 2.

Fig. 2

The mapping method developed by Wu and Watson (1997) applied to a three-disulfide-bond-containing intermediate of ONC; this scheme is illustrated with I2 as an example. The cysteines in ONC are numbered, and the native disulfide bonds are connected. The locations of the free cysteines are identified by the sizes of the fragments produced by the base cleavage.