Table 1. Characteristics of children in the four study groups.
Characteristics | Placebo n (%) | SP bimonthly n (%) | AS+AQ bimonthly n (%) | AS+AQ monthly n (%) | p-value |
Number of children enrolled | 650 (26.5) | 613 (25.0) | 562 (23.0) | 626 (25.5) | 0.553 |
Age (in months) (mean, SD) | 27.4 (14.9) | 27.6 (15.8) | 26.8 (15.7)† | 27.0 (15.8) | 0.002$ |
3–11 | 101 (15.5) | 124 (20.0) | 127 (22.9) | 136 (21.6)† | 0.007 |
12–23 | 193 (29.6) | 154 (24.9) | 139 (25.1) | 161 (25.6) | 0.197 |
24–35 | 162 (24.9) | 123 (19.9) | 113 (20.4) | 131 (20.8) | 0.113 |
36–47 | 106 (16.3) | 119 (19.2) | 104 (18.8) | 106 (16.9) | 0.453 |
48–59 | 86 (13.2) | 91 (14.7) | 70 (12.6) | 93 (14.8) | 0.617 |
Sex (male) | 329 (50.6) | 301 (49.1) | 278 (50.2) | 312 (49.8) | 0.959 |
Owns bednet | 186 (28.5) | 178 (28.8) | 169 (30.5) | 193 (30.7) | 0.780 |
Owns ITN | 90 (13.8) | 92 (14.9) | 86 (15.5) | 95 (15.1) | 0.862 |
Slept under bednet last night | 131 (20.1) | 119 (19.2) | 122 (21.7) | 127 (20.3) | 0.774 |
Slept under ITN last night | 61 (9.4) | 68 (11.0) | 67 (12.1) | 66 (10.5) | 0.497 |
Stunted | 0 | 1 (0.16) | 3 (0.53) | 2 (0.3) | 0.281* |
Wasted | 80 (12.3) | 61 (10.0) | 71 (12.6) | 85 (13.6) | 0.249 |
Underweight | 186 (28.6) | 165 (26.9) | 164 (29.2) | 179 (28.6) | 0.837 |
MUAC (cm) (mean, SD) | 15.5 (1.634) | 15.6 (1.554) | 15.6 (1.521) | 15.5 (1.624) | 0.277$ |
BMI (mean, SD) | 0.159 (0.024) | 0.160 (0.024) | 0.159 (0.026) | 0.160 (0.024) | 0.999$ |
G-6-PD Deficient | N = 124 18 (14.5) | N = 139 24 (17.3) | N = 119 20 (16.8) | N = 113 12 (10.6) | 0.459 |
Hb genotype | N = 110 | N = 116 | N = 98 | N = 80 | |
AA | 89 (80.9) | 70 (60.3) | 58 (59.2) † | 58 (72.5) | 0.001 |
AS | 15 (13.6) | 25 (21.2) | 16 (16.3) | 10 (12.5) | 0.289 |
AC | 3 (2.7) | 14 (12.1)† | 20 (20.4)† | 7 (8.6) | 0.006* |
SC | 3 (2.7) | 0 (0.0) | 3 (3.1) | 1 (1.3) | 0.283* |
CC | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (3.8) | - |
SS | 0 (0.0) | 7 (6.0)† | 1 (1.0) | 1 (1.3) | 0.011* |
p <0.05 for the individual intervention group compared to the placebo group
Fisher's Exact Test P values
ANOVA