Table 2 Summary of endoglin analysis in peripheral blood activated monocytes of patients with hereditary haemorrhagic telangiectasia (HHT).

Group	Mutation confirmed	n	Age (years)		Endoglin levels (%)
			Median	Range (25–75%)	Median	Range (25–75%)
HHT1	ENG	109	42.4	21.3	48.0*	19.0
HHT2	ALK‐1	61	42.2	22.3	91.0	37.0
Control	None	84	37.9	38.9	88.5	29.5

HHT1 and HHT2 refer to individuals with a confirmed mutation. The control group is composed of spouses of affected members, unrelated individuals, and non‐affected family members as confirmed by the absence of mutation. The endoglin level present on activated monocytes is expressed relative to a normal control ran in each experiment.

The two sided pair normal approximation obtained from the two sample Wilcoxon test is reported: *p<0.001 relative to HHT2 and control groups (level of significance α = 0.008).