Table 2.

Effects of Sub-Chronic Dosing with Clozapine and Haloperidol on [³H]SR141716A Binding

Data are expressed as means ± S.E.M. obtained from non-linear regression analyses of [3H]SR141716A binding.
Female Adults
	Prefrontal Ctx		Striatum
Drug	Bmax (nM)	KD (nM)	Bmax (nM)	KD (nM)
Saline	3.63 ± 0.37	0.73 ± 0.06	2.53 ± 0.14	0.67 ± 0.10
Clozapine	3.13 ± 0.28	0.73 ± 0.11	2.65 ± 0.28	1.02 ± 0.24
Haloperidol	3.83 ± 0.13	0.78 ± 0.06	3.08 ± 0.33	0.72 ± 0.14
Male Adults
	Prefrontal Ctx		Striatum
Drug	Bmax (nM)	KD (nM)	Bmax (nM)	KD (nM)
Saline	3.24 ± 0.33	0.63 ± 0.06	3.22 ± 0.41	1.57 ± 0.37
Clozapine	3.88 ± 0.46	0.72 ± 0.06	2.90 ± 0.43	1.32 ± 0.52
Haloperidol	3.71 ± 0.58	0.62 ± 0.05	3.64 ± 0.81	1.88 ± 0.85