Skip to main content
. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Cancer Res. 2008 Oct 1;68(19):7985–7994. doi: 10.1158/0008-5472.CAN-08-1418

Figure 6. The effect of ABT-737 and paclitaxel on colony formation in paclitaxel-resistant MCF-7 and MDA-MB-468 cells.

Figure 6

Figure 6

A, MCF-7 TaxR50 cells were treated with paclitaxel (300 nM), ABT-737 (300 nM) or combination of paclitaxel (300 nM) and ABT-737 (300 nM) for 16 h. MDA-MB-468 TaxR cells were treated with paclitaxel (100 nM), ABT-737 (200 nM) or combination of paclitaxel (100 nM) and ABT-737 (200 nM) for 16 h. Clonogenic survival was assessed by colony-forming assay. Data presented are percentage of colony formation normalized to untreated control cells. B, Model of alterations in BCL-2 protein family members governing paclitaxel resistance. I, paclitaxel sensitive cells. II, Paclitaxel-resistant cells, similar to MCF-7 TaxR50. III, Paclitaxel resistant cells, similar to MDA-MB-468 TaxR.