Table 2.
Training and experimental protocol for the Go/No-go procedure used in Experiment 2.
| Stage and days per stage 1 | Conditions | Mean (±SEM) sessions to completion |
|---|---|---|
| 1 (2 sessions) | Go trials only: Nose pokes during the light cue reinforced with 19.95 µl sucrose2. Each session consisted of 60 Go trials with cue periods of 30 s. | Female D4KO: 5.4 ± 0.7 |
| Female WT: 6.4 ± 1.0 | ||
| Male D4KO: 6.0 ± 0.6 | ||
| Male WT: 4.8 ± 0.4 | ||
| 2 (2 sessions) | Go trials only. Light cue period reduced to 10 s. | Female D4KO: 3.0 ± 0.44 |
| Female WT: 3.4 ± 0.9 | ||
| Male D4KO: 3.8 ± 1.4 | ||
| Male WT: 2.6 ± 0.4 | ||
| 3 (15 sessions) | No-go trials introduced: 19.95 µl sucrose delivered if no nose pokes occurred during 5-s tone cue. Each session consisted of 30 Go trials and 30 No-go trials with cue periods of 5 s. |
1
Notes. For Stages 1–2, mice advanced to the next stage after completing 2 consecutive sessions with 30 or more trials completed within 40 minutes.
2
The side location of the cup delivering the reward was counterbalanced across mice and across genotype.