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. Author manuscript; available in PMC: 2008 Dec 16.
Published in final edited form as: Lupus. 2004;13(6):413–422. doi: 10.1191/0961203304lu1045rr

Figure 2.

Figure 2

Regulation of LCK by CD45 and CSK. LCK is controlled by the reciprocal action of the protein tyrosine phosphatase CD45 and the protein tyrosine kinase CSK. a) CD45 dephosphorylates the regulatory Tyr-505 residue, promoting LCK to adopt its open conformation. Subsequently, LCK becomes fully activated by autophosphorylation of Tyr-394. b) Src-family kinases, LCK and FYN, entering lipid rafts phosphorylate the adapter molecule Cbp/PAG resulting in the recruitment of CSK from the cytosol. Recruited CSK phosphorylates raft localized LCK at Tyr-505 inducing its inactive. ‘tail-bite’ conformation.

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