Table 2. Enzyme kinetics parameter values used for polymerase-γ interaction with each activated analog, in order of decreasing k_cat/K_m.

NRTI	Km (µM)	kcat (sec−1)	kcat/Km (µM sec)−1	Vexo (sec−1)
ddC	0.041	0.660	16.1	0.00002
ddA	0.022	0.310	14.1	0.0005
d4T	0.045	0.24	5.33	0.0004
FTC(+)	0.79	0.84	1.1	0.0048
3TC(+)	1.5	0.35	0.23	0.02
Acyclovir	6	1.03	0.17	0.0021
ddI	6.3	0.15	0.024	0.0007
3TC(−)	9.2	0.125	0.01	0.015
TDF	40.3	0.21	0.005	0.0007
AZT2001	187	0.2	0.001	0.0004
ABC	13	0.0018	0.0014	0.0016
FTC(−)	62.9	0.0086	0.00014	0.0048
AZT2007	280	0.001	0.0000036	Not reported

Enzyme kinetics data taken from references [25]–[28].