Table 4. IC50 values for light strand termination calculated from the simulation.
| Analog | IC50Values (µM) with High dNTP | IC50 Values (µM) with Medium dNTP | IC50 Values (µM) with Low dNTP | Reported mtDNA Depletion | Citations for mtDNA Depletion |
| ddC-TP | 3.42×10−4 | 2.38×10−4 | 5.80×10−5 | Yes | [8],[11] |
| ddA-TP | 4.42×10−4 | 2.89×10−4 | 7.47×10−5 | Yes | [8],[11] |
| d4T-TP | 7.92×10−4 | 4.65×10−4 | 9.76×10−5 | Yes | [8],[11] |
| FTC(+)-TP | 5.90×10−3 | 4.20×10−3 | 9.80×10−4 | No data | NA |
| 3TC(+)-TP | 3.54×10−2 | 2.26×10−2 | 6.30×10−3 | No data | NA |
| Acyclovir-TP | 6.78×10−2 | 2.58×10−2 | 3.81×10−3 | No data | NA |
| ddI-TP | 0.25 | 0.17 | 4.60×10−2 | No data | NA |
| 3TC(−)-TP | 0.56 | 0.40 | 8.40×10−2 | No | [11],55 |
| TDF-TP | 1.18 | 0.87 | 0.22 | No | [68],[69] |
| AZT2001-TP | 3.95 | 2.38 | 0.50 | No | [9], [11], [18], [19], [56]–[62] |
| FTC(−)-TP | 778.9 | 58.59 | 7.57 | No | |
| ABC-TP | NA | NA | 8.10 | No | [15] |
| AZT2007-TP | NA | NA | NA | No | [9], [11], [18], [19], [56]–[62] |
Analogs are listed in order of increasing IC50. IC50 values are calculated for three different sets of mitochondrial dNTP levels; high, medium and low, as defined in Table 3. NA, not applicable.