Fig. 1.
Following transient MCAO, Egr1 mRNA levels increased significantly in the ipsilateral cortex of adult rats and mice between 2 h to 5 days of reperfusion compared to respective sham controls. The bars in the histogram (A) represent mean ± SD (n = 5/group) of fold change over sham. For each sample, PCR was conducted in triplicate. *p < 0.05 versus sham by one-way ANOVA followed by Dunnett's multiple comparisons post-test. Real-time PCR amplification plots for 18s RNA and Egr1 of representative mice subjected to sham-operation and 2 h reperfusion and 1 day reperfusion following MCAO is shown in panel b.