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. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Biochemistry. 2008 Aug 2;47(34):8840–8854. doi: 10.1021/bi800301b

Figure 8. Structure-activity relationships for Kvβ2-mediated reduction of substituted benzaldehydes.

Figure 8

Relationship between log (A) kcat/Km, (B) kcat and (C) Km of para-substituted benzaldehydes and the Hammett constant - σ+. The enzyme activity was determined under multiple turnover condition with 0.15 mM NADPH. Data are shown as discrete points and the lines are best weighted fits of a linear equation to the data (R=0.79-0.93). Calculated slope values are listed on the upper right hand corner of the panel. Results of multivariate regression analysis are shown in supplemental Table 1.