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. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Biochemistry. 2008 Aug 2;47(34):8840–8854. doi: 10.1021/bi800301b

Scheme 1. Potential products of 4-oxo-2-nonenal (ONE) reduction.

Scheme 1

Reduction of 4-oxo-2-nonenal at C-1 aldehyde would lead to the formation of 4-oxo-2-nonenol, whereas reduction of the C-4 keto group should yield 4-hydroxy-2-nonenal (HNE). Additional reduction of HNE or 4-oxo-2-nonenol would form 1,4-dihydroxy-2-nonenal (DHN). Note: Reduction in the presence of Kvβ2 led to the appearance of only 4-oxo-2-nonenol and no HNE or DHN formation was observed (see, Fig. 4). The reduction of the C-1 aldehyde to an alcohol is indicated by a dotted box.