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. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Biochemistry. 2008 Aug 2;47(34):8840–8854. doi: 10.1021/bi800301b

Table 2.

Kvβ2 specific activity with biologic carbonyls.

Substrate Structure Specific activity (min−1)
1. Phenylglyoxal (100 μM) graphic file with name nihms-69596-t0001.jpg 0.014 ± 0.0006
2. Methylglyoxal (12 mM) graphic file with name nihms-69596-t0002.jpg 0.32 ± 0.04
3. 3-deoxyglucosone (5 mM) graphic file with name nihms-69596-t0003.jpg 0.039 ± 0.01
4. 2-carboxybenzaldehyde (10
mM)
graphic file with name nihms-69596-t0004.jpg 0.010 ± 0.005
5. Acrolein (100 μM) graphic file with name nihms-69596-t0005.jpg 0.010 ± 0.003
6. 4-oxo-nonenal (100 μM) graphic file with name nihms-69596-t0006.jpg 0.028 ± 0.004
7. 4-hydroxy-nonenal (100 μM) graphic file with name nihms-69596-t0007.jpg --a
8. Succinic semialdehyde (25 mM) graphic file with name nihms-69596-t0008.jpg 0.011 ± 0.004
9. 12-oxoETE (10 μM) graphic file with name nihms-69596-t0009.jpg 0.044 ± 0.007
10. PGJ2 (100 μM) graphic file with name nihms-69596-t0010.jpg 0.086 ± 0.019
11. PGD2 (100 μM) graphic file with name nihms-69596-t0011.jpg --a
12. PGF (100 μM) graphic file with name nihms-69596-t0012.jpg --a
13. 9, 10 Phenanthrenequinone
(200 μM)
graphic file with name nihms-69596-t0013.jpg 0.19 ± 0.07
14. POVPC (100 μM) graphic file with name nihms-69596-t0014.jpg 0.078 ± 0.016
15. 5α-androstan-17β-ol-3-one
(100 μM)
graphic file with name nihms-69596-t0015.jpg --a
16. Cortisone (100 μM) graphic file with name nihms-69596-t0016.jpg --a
a

Activity less than two fold over the background.