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A) Representative autoradiograph of electrophoretic shift assay (EMSA) of specific binding of HIF-1α nuclear protein. Increased activity of HIF-1α was detected in hypertrophic myocardium under normoxic conditions with further elevation under hypoxia. As a positive HIF-1α control, nuclear extracts were obtained from COS-7 (COS) cells treated with 0.15 mM CoCl2 for 16 hours and subjected to parallel EMSAs. B) Densitometry analysis of HIF-1α EMSAs.
