Table 2. Matches Found in Swiss-Prot Database.
Hormones | Sequence Matching “Hits” | Hormones | Sequence Matching “Hits” |
ACTH | x | MCH (melanin concentrating hormone) | |
ADM (adrenalmedulin) | x | Motilin | x |
Agouti-related peptides | x | MSH (melanocyte stimulating hormone) | x |
Amylin | x | Neuromedin U | x |
ANP (atrial natruretic peptide) | Neurotensin | x | |
Apelin | Neurturin | x | |
Calcitonin | x | Nociceptin | x |
CART (cocaine and amphetamine regulated transcript) | x | NPY (neuropeptide Y) | x |
CCK (cholecystokinin) | x | Orexins | x |
CGRP (calcitonin gene related protein) | x | Oxytocin | x |
CNP (C-type natriuretic factor) | x | PACAP (pituitary adenylate cyclase activating polypeptide) | x |
Cortistatin | PPY (pancreatic hormone) | x | |
CRF (corticotropin releasing factor) | x | PHI (same precursor with VIP) | x |
Dynorphin | x | PrRP (prolactin-releasing peptide) | |
β-Endorphin | x | PTH (parathyroid hormone) | x |
Endothelin 1 | x | PTH-RP (parathyroid releasing hormone) | |
Endothelin 2 | x | PYY (peptide YY) | x |
Endothelin 3 | x | Secretin | x |
Enkephalin | x | Somatostatin | |
Galanin | x | Substance K ( = neurokinin A) | |
Gastrin | x | Substance P | x |
Glucagon | x | TEGT (testis enhanced gene transcript) | x |
GRF (growth hormone releasing factor) | x | TRH (thyroid releasing hormone) | x |
GRP (gastrin releasing peptide) | Vasopressin | x | |
Guanylin | VIP (vasoactive intestinal peptide) | x | |
LHRH1 (luetinizing hormone releasing hormone) | x | PSP94 (prostate secretory protein) | x |
False Positives
Other signaling molecules: FGF-3,5,7,10,17,18; GDNF; CD8,28; PDGF-2; TGF; VEGF (vascular endothelial growth factor); HBNF-1; MIP; NGF (nerve growth factor); Cytokine A21, IFN-α (interferon alpha); IGF binding protein 1B,2,3; IL7 (interleukin 7).
Other: MAGF (microfibril associated protein), MINK (K-channel), K-channel related peptide, L-type Ca2+ channel, gamma subunit, myelin Po protein, Dif-2, Eosinophil, Syntaxin 1B (vesicle docking), Syntaxin 2, TMP21 (vesicle trafficking protein), Coagulation factor III, PGD2 synthase, syndecans, FKBP12 (FK506 binding protein), Folate receptor, ERp29, COMT, Connexin 32, Cytostatin.