Figure 6.
Effect of peripherally administered nadolol on brain IL-1 production following peripheral E.coli challenge. Rats were injected i.p. with either saline (Sal) or nadolol (Nad; β-antagonist) immediately prior to challenge with i.p. saline or E.coli. Animals were sacrificed 6 h later for measurement of IL-1 by ELISA. Bars represent group averages +/− SEM (n=8–9/group). * represents p < 0.05 compared to saline-injected controls. # represents p < 0.05 compared to E.coli group receiving i.p. saline.