Bilateral microinjections, administered into the lateral septum (LS), of either the α1-adrenergic receptor antagonist benoxathian (2.0 nmole/side), or a cocktail of β1β2-receptor antagonists betaxolol + ICI 118,551 (1.0 nmole each/side), attenuated defensive burying behavior and increased immobility on the shock-probe defensive burying test (n=8–18/group; *p<0.05 compared to vehicle control group). Note that in this experiment, because a number of LS-implanted rats did not exhibit any burying behavior, burying time was analyzed non-parametrically; nonetheless, only the reduction caused by benoxathian achieved significance in comparison to vehicle-treated rats in this analysis. By contrast, immobility was normally distributed, and both of the drug treatment effects were significant for this measure. Adapted and reprinted, with permission from Elsevier, from (35).