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. Author manuscript; available in PMC: 2009 Aug 25.
Published in final edited form as: Chem Biol. 2008 Aug 25;15(8):765–770. doi: 10.1016/j.chembiol.2008.07.010

Figure 1.

Figure 1

(A) The structures of the antimalarial compounds FR900098 and fosmidomycin. Both inhibit DXR, an essential enzyme in the isoprenoid biosynthetic pathway in malaria-causing parasites. (B) The initial reactions in the biosynthesis of 2-aminoethylphosphonic acid, fosfomycin, and bialaphos. In the first step, catalyzed by PEP mutase, phosphoenolpyruvate is rearranged to phosphonopyruvate, which is then decarboxylated to yield phosphonoacetaldehyde in a reaction catalyzed by phosphonopyruvate decarboxylase.