Figure 8. Antagonism of PCP treatment on PN7, 9, and 11-induced down-regulation on NR1 in the striatum.
Quantitative analysis reveals that pretreatment with olanzapine prevents PCP-induced (10 mg/kg, N=5–15/treatment) down-regulation of NR1 in the striatum. PCP treatment had no effect on protein levels of NR2A *p <0.05 vs. SAL NR1 (one-way ANOVA with Bonferroni's post hoc test)