TABLE 3.
−8202A/G genotypes, their association with the risk of thoracic aortic aneurysm and thoracic aortic dissection, and G allele frequencies in patients and control subjects
| Control subject (n = 111) | Patients with TAA (n = 28) | Patients with TAD (n = 60) | Patients with TAA or TAD (n = 85) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | No. | % | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) |
| Odds ratios and their 95% confidence intervals were calculated with logistic regression, with the MMP9 variant genotype AA as the reference group, and adjusted for age and sex. TAA, Thoracic aortic aneurysm; TAD, thoracic aortic dissection; OR, odds ratio; Cl, confidence interval. | ||||||||||||||
| AA | 46 | 41.4 | 1 | 3.6 | 1.00 | 1.00 | 7 | 11.7 | 1.00 | 1.00 | 8 | 9.4 | 1.00 | 1.00 |
| AG | 50 | 45.1 | 25 | 89.3 | 23.00 (3.00-176.62) | 15.42(1.77-134.18) | 39 | 65.0 | 5.13(2.09-12.59) | 4.02(1.57-10.32) | 63 | 74.1 | 7.25(3.14-16.74) | 4.96 (2.04-12.07) |
| GG | 15 | 13.5 | 2 | 7.1 | 6.13 (0.52-72.52) | 6.81 (0.48-96.87) | 14 | 23.3 | 6.13(2.09-18.03) | 5.19(1.61-16.74) | 14 | 16.5 | 5.37(1.89-15.28) | 4.52(1.42-14.37) |
| AG + GG | 65 | 58.6 | 27 | 96.4 | 19.11 (2.51-145.68) | 13.80(1.60-119.15) | 53 | 88.3 | 5.36(2.24-12.84) | 4.26(1.70-10.66) | 77 | 90.6 | 6.81 (3.00-15.47) | 4.87(2.04-11.64) |
| G allele frequency | 0.36 | 0.52 | 0.56 | 0.54 | ||||||||||