TABLE 4.
IVS4+3G/T genotypes, their association with the risk of thoracic aortic aneurysm and thoracic aortic dissection, and T allele frequencies in patients and control subjects
| Control subjects (n = 111) | Patients with TAA (n = 28) | Patients with TAD (n = 60) | Patients with TAA or TAD (n = 85) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | No. | % | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) |
| Odds ratios and their 95% confidence intervals were calculated with logistic regression, with the MMP9 variant genotype (GG) as the reference group, and adjusted for age and sex. TAA, Thoracic aortic aneurysm; TAD, thoracic aortic dissection; OR, odds ratio; Cl, confidence interval. | ||||||||||||||
| GG | 83 | 74.8 | 21 | 75.9 | 1.00 | 1.00 | 45 | 75.4 | 1.00 | 1.00 | 64 | 75.6 | 1.00 | 1.00 |
| TG | 26 | 23.4 | 7 | 24.1 | 12 | 19.7 | 18 | 20.9 | ||||||
| TT | 2 | 1.8 | 0 | 0 | 0.99 (0.38-2.57) | 0.65(0.19-2.28) | 3 | 4.9 | 0.99 (0.48-2.04) | 0.86(0.38-1.92) | 3 | 3.5 | 0.97(0.51-1.87) | 0.78(0.36-1.67) |
| T allele frequency | 0.14 | 0.13 | 0.15 | 0.14 | ||||||||||