TABLE 5.
2003A/G (Q668R) genotypes, their association with the risk of thoracic aortic aneurysm and thoracic aortic dissection, and A allele frequencies in patients and control subjects
| Control subjects (n = 111) | Patients with TAA (n = 28) | Patients with TAD (n = 60) | Patients with TAA or TAD (n = 85) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | No. | % | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) | No. | % | Crude OR (95% Cl) | Adjusted OR (95% Cl) |
| Odds ratios and their 95% confidence intervals were calculated with logistic regression, with the MMP9 variant genotype (GG) as the reference group, and adjusted for age and sex. TAA, Thoracic aortic aneurysm; TAD, thoracic aortic dissection; OR, odds ratio; Cl, confidence interval. | ||||||||||||||
| GG | 84 | 75.7 | 21 | 75.9 | 1.00 | 1.00 | 45 | 75.4 | 1.00 | 1.00 | 64 | 75.6 | 1.00 | 1.00 |
| AG | 25 | 22.5 | 7 | 24.1 | 12 | 19.7 | 18 | 20.9 | ||||||
| AA | 2 | 1.8 | 0 | 0 | 1.04(0.40-2.71) | 0.68(0.19-2.41) | 3 | 4.9 | 1.04(0.50-2.15) | 0.92(0.41-2.07) | 3 | 3.5 | 1.02(0.53-1 .97) | 0.84(0.39-1.79) |
| A allele frequency | 0.13 | 0.13 | 0.15 | 0.14 | ||||||||||