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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2008 Aug 7;45(5):650–660. doi: 10.1016/j.yjmcc.2008.07.017

Figure 3.

Figure 3

Regional ischemia induces heterogeneity of ΔΨm and ROS signals. Forty minutes of ischemia, initiated by LAD occlusion, precipitated marked cell-to-cell heterogeneity of ΔΨm (upper (panels) that correlated with oxidative stress (middle panels). As indicated in the overlays (lower panels), the highest levels of CM-DCF fluorescence corresponded to cells with completely depolarized mitochondria, which became more pronounced after reperfusion. Scale bar equals 40 microns. Fluorescence intensity is represented by a pseudocolor lookup table between 0 and 255 units, as indicated.