Figure 7.
ΔΨm loss is correlated with ROS increase in intact perfused hearts treated with BSO and diamide. a) ΔΨm is markedly depolarized (upper panels) in many cells after thiol depletion in intact myocardium in association with increased oxidation of the CM-DCF ROS probe (lower panels). b) The reduction in average TMRE fluorescence after BSO plus diamide application. Scale bar in a equals 20 microns