Table 1.
Gene clusters enriched in AKR islets versus Bl6 islets
| Gene | Gene ID* | Fold Change | AffyID† | |||
|---|---|---|---|---|---|---|
| Signal (category; sp_pir_keywords); upregulated in AKR | ||||||
| Serine (or cysteine) peptidase inhibitor, clade a, member 1d | NM_009243, NM_009244, NM_009245, NM_009246, NM_009247 | 25.5, 19.6, 10.9 | 1420553_x_at, 1418282_x_at, 1451513_x_at | |||
| Glucagon-like peptide 1 receptor | NM_021332 | 21.1 | 1458719_at | |||
| Apolipoprotein F | NM_133997 | 12.9 | 1418239_at | |||
| Inter-alpha trypsin inhibitor, heavy chain 1 | NM_008406 | 10.1 | 1417973_at | |||
| Dehydrogenase/reductase (sdr family) member 8 | NM_053262 | 9.1 | 1421011_at | |||
| Syndecan 4 | NM_011521 | 7.5 | 1448793_a_at | |||
| Astrotactin 1 | NM_007495 | 4.9 | 1418615_at | |||
| Ciliary neurotrophic factor receptor | NM_016673 | 4.2 | 1419429_at | |||
| Sparc-like 1 (mast 9, hevin) | NM_010097 | 3.7 | 1416114_at | |||
| Neuroblastoma, suppression of tumorigenicity 1 | NM_008675 | 3.3 | 1448428_at | |||
| Glial cell line derived neurotrophic factor family receptor alpha 1 | NM_010279 | 3.1 | 1450440_at | |||
| Histocompatibility 2, d region locus 1‡ | NM_010380 | 2.7 | 1450170_x_at | |||
| Interleukin 6 signal transducer | NM_010560 | 2.7 | 1437303_at | |||
| Periostin, osteoblast specific factor | NM_015784 | 2.6 | 1423606_at | |||
| Jagged 2 | NM_010588 | 2.4 | 1426430_at | |||
| Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 | NM_009262 | 2.5, 1.7 | 1419672_at, | |||
| 1419673_at | ||||||
| Folate receptor 1 (adult) | NM_008034 | 2.4 | 1450995_at | |||
| Epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | NM_021474 | 2.3 | 1417018_at | |||
| Spondin 2, extracellular matrix protein | NM_133903 | 2.2 | 1417860_a_at | |||
| Secretory granule neuroendocrine protein 1, 7b2 protein | NM_009162 | 2.2 | 1423150_at | |||
| Asporin | NM_025711 | 2.2 | 1416652_at | |||
| Apolipoprotein A-II | NM_013474 | 2.1 | 1417950_a_at | |||
| Serine (or cysteine) peptidase inhibitor, clade I member 1 | NM_009250 | 1.9 | 1416702_at | |||
| Protease, serine, 23 | NM_029614 | 1.9 | 1431057_a_at | |||
| Vitronectin | NM_011707 | 1.9 | 1455098_a_at | |||
| Phospholipase A2, group XIIa | NM_023196, NM_183423 | 1.8 | 1452026_a_at | |||
| Signal (category; sp_pir_keywords); downregulated in AKR | ||||||
| Angiogenin, ribonuclease a family, member 1 | NM_007447 | −579.1 | 1438936_s_at | |||
| −11.0 | 1438937_x_at | |||||
| Histocompatibility 2, D region locus 1‡ | NM_010380 | −68.5, −48.4, −31.0, −4.1 | 1425545_x_at | |||
| 1426324_at | ||||||
| 1451683_X_AT, | ||||||
| 1451931_X_AT | ||||||
| Histocompatibility 2, K1, K region | NM_001001892 | −38.8, −21.9, −2.30 | 1425336_x_at, 1427746_x_at, 1451784_x_at | |||
| Kallikrein 1-related peptidase b5 | NM_008456 | −13.0, −14.4 | 1419010_x_at, | |||
| 1449313_at | ||||||
| Galanin | NM_010253 | −10.9 | 1460668_at | |||
| Trefoil factor 2 (spasmolytic protein 1) | NM_009363 | −6.6 | 1422448_at | |||
| Serine (or cysteine) peptidase inhibitor, clade I, member 2 | NM_026460 | −6.1 | 1425152_s_at | |||
| Phospholipase a2, group Ib, pancreas | NM_011107 | −5.4, −5.0 | 1416626_at, | |||
| 1437015_x_at | ||||||
| Left right determination factor 1 | NM_010094 | −5.2 | 1417638_at | |||
| Complement component 8, beta subunit | NM_133882 | −5.0 | 1427472_a_at | |||
| Phospholipase a2, group IIF | NM_012045 | −4.6 | 1434852_at | |||
| Kallikrein 1-related peptidase b22 | NM_010114, NM_010116 | −4.5 | 1425182_x_at | |||
| Fxyd domain-containing ion transport regulator 3 | NM_008557 | −4.5 | 1418374_at | |||
| Islet neogenesis associated protein-related protein | NM_013893 | −4.5 | 1424009_at | |||
| Polymeric immunoglobulin receptor | NM_011082 | −4.4 | 1450060_at | |||
| Kallikrein 1 | NM_010639 | −4.3 | 1415837_at | |||
| Insulin-like growth factor 1 | NM_010512, NM_184052 | −4.3 | 1452014_a_at | |||
| Hydroxysteroid (17-beta) dehydrogenase 13 | NM_198030 | −4.2 | 1460606_at | |||
| Fxyd domain-containing ion transport regulator 6 | NM_022004 | −4.0 | 1417343_at | |||
| Chemokine (c-c motif) ligand 28 | NM_020279 | −4.03 | 1455577_at | |||
| Serine peptidase inhibitor, kazal type 3 | NM_009258 | −4.0 | 1415938_at | |||
| Interleukin 11 receptor, alpha chain 2 | NM_010549,NM_010550 | −3.9 | 1417505_s_at | |||
| Kallikrein 1 | NM_010639 | −3.9 | 1415837_at | |||
| Amylase 1, salivary | NM_007446 | −3.6 | 1417765_a_at | |||
| Complement component 1, q subcomponent, c chain | NM_007574 | −3.5 | 1449401_at | |||
| Matrilin 2 | NM_016762 | −3.4 | 1419442_at | |||
| Glycoprotein 2 (zymogen granule membrane) | NM_025989 | −3.4 | 1449452_a_at | |||
| Pancreatic lipase-related protein 2 | NM_011128 | −3.26, −2.96 | 1437438_x_at, 1448186_at | |||
| Osteoglycin | NM_008760 | −3.25, −2.17 | 1419662_at, 1419663_at | |||
| Complement component 1, q subcomponent, beta polypeptide | NM_009777 | −3.0 | 1417063_at | |||
| Deleted in malignant brain tumors 1 | NM_007769 | −3.7 | 1418287_a_at | |||
| CD200 antigen | NM_010818 | −3.0 | 1448788_at | |||
| Contactin associated protein-like 2 | NM_025771, NM_001004357 | −3.0 | 1422798_at | |||
| Stromal cell derived factor 4 | NM_011341 | −2.9 | 1440340_at | |||
| Histocompatibility 2, class II antigen a, alpha | NM_010378 | −2.8 | 1435290_x_at | |||
| Protein tyrosine phosphatase, receptor type, t | NM_021464 | −2.8 | 1439725_at | |||
| Transmembrane emp24 protein transport domain containing 6 | NM_025458 | −2.7 | 1416490_at | |||
| Contactin associated protein-like 2 | NM_025771, NM_001004357 | −2.7 | 1422798_at | |||
| Prominin 1 | NM_008935 | −2.6 | 1419700_a_at | |||
| MHC (a.ca/j(h-2k-f) class I antigen | NM_019909, NM_001001892 NM_010380 | −2.6 | 1424948_x_at | |||
| Cathepsin S | NM_021281 | −2.5 | 1448591_at | |||
| Platelet-derived growth factor receptor, alpha polypeptide | NM_011058 | −2.5 | 1421917_at | |||
| Cathepsin H | NM_007801 | −2.4 | 1418365_at | |||
| Activated leukocyte cell adhesion molecule | NM_009655 | −2.4, | 1426300_at, | |||
| −2.1, | 1426301_at, | |||||
| −2.0 | 1437466_at | |||||
| Macrophage expressed gene 1 | XM_890648, XM_129176 | −2.4 | 1427076_at | |||
| Delta/notch-like EGF-related receptor | NM_152915 | −2.3, | 1423671_at, | |||
| −2.3 | 1456379_x_at | |||||
| Regenerating islet-derived 1 | NM_009042 | −2.1 | 1415905_at | |||
| Signal sequence receptor, alpha | NM_025965 | −2.1 | 1441327_a_at | |||
| Torsin family 3, member a | NM_023141 | −2.0 | 1428660_s_at | |||
| Protein tyrosine phosphatase, receptor type, j | NM_008982 | −2.0 | 1455030_at | |||
| Protein tyrosine phosphatase, receptor type, d | NM_001014288 NM_011211 | −1.8 | 1445767_at | |||
| HTRA serine peptidase 1 | NM_019564 | −1.8 | 1416749_at | |||
| Fibrinogen-like protein 2 | NM_008013 | −1.8 | 1421855_at | |||
| Gamma-glutamyl hydrolase | NM_010281 | −1.8 | 1419595_a_at | |||
| Extracellular region (category; goterm_cc_all); upregulated in AKR | ||||||
| Sparc-like 1 (mast 9, hevin) | NM_010097 | 3.7 | 1416114_at | |||
| Periostin, osteoblast specific factor | NM_015784 | 2.6 | 1423606_at | |||
| Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 | NM_009262 | 2.5, 1.7 | 1419672_at, 1419673_at | |||
| Epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | NM_021474 | 2.3 | 1417018_at | |||
| Spondin 2, extracellular matrix protein | NM_133903 | 2.2 | 1417860_a_at | |||
| Asporin | NM_025711 | 2.2 | 1416652_at | |||
| Vitronectin | NM_011707 | 1.9 | 1455098_a_at | |||
| Fatty acid desaturase (category; interpro_name); upregulated in AKR | ||||||
| Stearoyl-coenzyme a desaturase 2 | NM_009128 | 3.6, 2.1 | 1415822_at, 1415824_at | |||
| Stearoyl-coenzyme a desaturase 1 | NM_009127 | 2.3 | 1415964_at | |||
| Fatty acid desaturase 2 | NM_019699 | 2.1 | 1449325_at | |||
*
NCBA accession Refseq mRNA (http://www.ncbi.nlm.nih.gov).
†
AffymetrixID (www.affymetrix.com).
‡
Histocompatibility 2, d region locus 1 (NM_010380) is probed by 5 separate Affymetrix probe sets, of which one is upregulated in AKR islets while the rest are downregulated (29). Histocompatibility 2, d region.