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The effect of VT on lung cAMP concentration after 80 min of ventilation of isolated mouse lungs without and with pretreatment with 10 μM BAY 60-7550 (n = 5–7). Values are means ± SE. *P < 0.05 vs. 6 ml/kg VT; #P < 0.05 vs. 20 ml/kg VT without BAY 60-7550 pretreatment.