Table 3.
Echocardiographic Parameters
| Baseline (SEM) | Months 0 to 3 Mean Difference* | Significance (p value)† | Months to 3 to 9 Mean Difference | Significance (p value)† | |
|---|---|---|---|---|---|
| LV Size | |||||
| LVM/ht2.7 (g/m2.7) | 49 (2.3) | 3.0 (−0.1–6.1) | NS | 6.3 (2.4–10.2) | <0.005 |
| RWT (mm) | 42 (0.9) | 0.3 (−1.8–2.4) | NS | −0.2 (−2.1–1.7) | NS |
| Systolic Function | |||||
| LVEF (%) | 63 (1.4) | 1.2 (−2.2–4.6) | NS | −2.1 (−5.9–1.7) | NS |
| FS (%) | 33 (1.1) | 0.4 (−1.8–2.7) | NS | −1.3 (−4.4–1.9) | NS |
| Sms (cm/sec) | 9.1 (0.2) | −0.1 (−0.8–0.6) | NS | 0.4 (−0.3–1.1) | NS |
| Diastolic Function | |||||
| E (cm/sec) | 79 (2.5) | −16.0 (−23.6 – −8.4) | <0.0001 | −11.0 (−18.7 – −3.3) | <0.01 |
| A (cm/sec) | 75 (3.1) | − 3.2 (−11.1–4.7) | NS | 0.8 (−6.5–8.0) | NS |
| Dec time (msec) | 222 (7.1) | 23.8 (5.4–42.1) | < 0.05 | 19.1(−6.5–44.7) | NS |
| Ems | 10 (0.3) | −0.4 (−1.3–0.6) | NS | 0.4 (−0.4–1.1) | NS |
Abbreviations: LV – left ventricle; LVEF – left ventricular ejection fraction; FS – fractional shortening; Sms – tissue Doppler systolic velocity; E – early mitral inflow velocity; A – late mitral inflow velocity; Dec Time – deceleration time; Ems – tissue Doppler diastolic velocity; LVM/ht2.7 – left ventricular mass/height2.7; RWT – relative wall thickness; NS – not significant.
*
Mean Difference is a decrease in the outcome value unless indicated by a negative value.
†
Significance for a difference at alpha <0.05.