Table 1.
μCT analysis of trabecular bone parameters in vertebrae (mean ± SEM). of N = 7-8 mice per group
| Wild type | Haploinsufficient | Null | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | 10 wk | 14 wk Vehicle | 14 wk PTH | 10 wk | 14 wk vehicle | 14 wk PTH | 10 wk | 14 wk vehicle | 14 wk PTH |
| Bone volume fraction (BV/TV) | 23.2 ± 0.9 | 24.3 ± 1.3 | 30.0 ± 0.8 b | 18.3 ± 0.8 | 20.2 ± 0.7 c | 26.2 ± 0.7 b | 14.2 ± 0.3 a | 10.7 ± 0.4 c, a | 13.9 ±0.5 b |
| Trabecular thickness (μm) | 48.2 ± 0.7 | 51.8 ± 0.7 | 52.2 ± 0.8 | 44.8 ± 1.7 | 50.5 ± 1.1 | 52.5 ± 1.1 | 45.0 ± 0.5 | 46.3 ± 0.8 c | 50.9 ± 1.1 b |
| Trabecular number (per mm) | 5.01 ± 0.90 | 4.58 ± 0.14 | 5.39 ± 0.17 b | 4.61 ± 0.07 | 4.07 ± 0.10 c, a | 4.80 ± 0.79 | 3.86 ± 0.03 | 3.14 ±0.05 c, a | 3.36 ± 0.09 |
| Trabecular spacing (μm) | 193 ± 3 | 213 ± 8 | 187 ± 6 b | 211 ± 4 | 241 ± 7 c | 200 ± 3 b | 252 ± 6 | 315 ± 6 c, a | 289 ± 7 b |
| Connectivity density (per mm3) | 201 ±11 | 154 ± 9 a | 481 ± 18 b, a | 165 ± 3 | 130 ±6 a, c | 292 ± 28 b | 144 ± 7 | 63 ± 3 c, a | 86 ± 5 b |
a
significantly different from corresponding 10 week, p ≤ 0.02
b
significantly different from corresponding vehicle treated, p ≤ 0.02
c
significantly different from vehicle treated wild type, p ≤ 0.02