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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Bone. 2008 Apr 13;43(2):264–273. doi: 10.1016/j.bone.2008.03.024

Table 5.

OPG and RANKL mRNA levels (relative to 0 nM PTH) in bone marrow cells cultured for 6 days with up to 10 nM PTH (mean ± SEM). N = 3

Wild type Null
mRNA 0 nM PTH 1 nM PTH 10 nM PTH 0 nM PTH 1 nM PTH 10 nM PTH
OPG 100 ± 30 14 ± 1 a 9 ± 0.5 a 100 ± 19 41 ± 2 30 ± 2
RANKL 100 ± 16 175 ± 26 360 ± 19 a 100 ± 6 255 ± 27 a 540 ± 37 a, b
RANKL:OPG (absolute ratio) 0.41 ± 0.07 4.49 ± 0.64 a 15.27 ± 0.70 a 0.43 ± 0.07 2.46 ± 0.14 a 7.19 ± 0.11 a, b
a

significantly different from corresponding 0 nm PTH, p ≤ 0.02

b

significantly different from corresponding wild type, p ≤ 0.01