Fig. 1.
Effect of adenosine2A receptor (A2AR) inhibition on the responsiveness of isolated, perfused Dahl salt-resistant (SR) rat kidneys to 10 μg of 2-chloroadenosine (2-CA) under normal salt (NS; 0.4% NaCl) intake. A: vascular response to 10 μg of 2-CA was assessed before and after A2AR blockade by 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl) phenol (ZM 241385; 1 μM). B: total release of epoxyeicosatrienoic acids (EETs) plus dihydroxyeicosatrienoic acids (DHTs) in response to 10 μg of 2-CA was compared in the absence and presence of ZM 241385 (1 μM). Data are means ± SE; n = 3. *P < 0.05 vs. control.