Fig. 5.

p75^NTR-IR in urinary bladder sections after intravesical infusion of anti-p75^NTR and application of species-specific secondary antibodies to demonstrate penetration of the antibody into the urinary bladder with intravesical infusion. Epifluorescence images of rat urinary bladder after intravesical infusion of anti-p75^NTR (100 μg/ml; A) and rat urinary bladder after only intravesical infusion of protamine sulfate (B). A: p75^NTR-IR is observed in urothelium and lamina propria, with staining reduced with increasing distance from the bladder lumen. B: no p75^NTR-IR was observed in rat urinary bladder in the absence of intravesical antibody infusion. U, urothelium; LP, lamina propria; l, lumen. Calibration bar represents 120 μm.