Table 1.
Effects of intravesical infusion of an anti-p75NTR monoclonal antibody on cystometric parameters
| Intravesical Infusion | Threshold Pressure, cmH2O | Micturition Pressure, cmH2O | Baseline Pressure, cmH2O | NVCs per Micturition Cycle | |
|---|---|---|---|---|---|
| Control (no CYP) | No antibody | 15.1±0.9 | 38.5±1.3 | 15.1±0.9 | 0.7±0.3 |
| Anti-p75NTR monoclonal antibody | 14.2±1.0 | 39.5±2.0 | 15.0±0.6 | 0.8±0.3 | |
| 48-h CYP | No antibody | 19.3±0.7* | 46.7±1.4* | 20.0±0.8* | 0.2±0.1* |
| Anti-p75NTR monoclonal antibody | 13.9±1.1 | 44.1±2.0 | 14.0±1.0 | 0.3±0.1 |
Values are means ± SE.
P ≤ 0.001 compared with isotype-matched IgG infusion in control rats; n = 4–11 rats in each group. Effects of intravesical infusion of an anti-p75NTR monoclonal antibody on baseline pressure, threshold pressure, micturition pressure, and numbers of nonvoiding contractions (NVCs) per micturition cycle are indicated. Threshold pressure and micturition pressure were significantly increased after 48-h cyclophosphamide (CYP) treatment. No effects of anti-p75NTR monoclonal antibody on threshold pressure, baseline pressure, or peak micturition pressure were observed. The no antibody group received intravesical infusion of protamine sulfate (PS; 10 mg/ml), which did not differ from rats receiving intravesical infusion of PS and isotype-matched IgG.